本文引用：吳澎濘, 熊帥, 蔣曉涵, 張怡, 梁超, 陳敏. 基於5-羥色胺治療腸易激綜合徵的中西醫研究進展[J]. 中國全科醫學, DOI: 10.12114/j.issn.1007-9572.2022.0034.
WU Pengning, XIONG Shuai, JIANG Xiaohan, ZHANG Yi, LIANG Chao, CHEN Min. Research Progress of Traditional Chinese and Western Medicine in the Treatment of Irritable Bowel Syndrome Based on 5-hydroxytryptamine[J]. Chinese General Practice, DOI: 10.12114/j.issn.1007-9572.2022.0034.
摘要： 腸易激綜合徵（IBS）是一種非胃腸道結構損害和生化異常的胃腸功能紊亂性疾病，其致病機制尚不十分清楚，西醫採用多種藥物、心理療法、調節飲食等方式進行治療，但效果欠佳。近年中醫藥治療IBS受到廣泛關注，尤其是便秘型與腹瀉型，眾多實驗中針對5-羥色胺（5-HT）訊號通路的中醫藥實驗居多，且多獲良效，故本文總結中醫藥基於5-HT治療IBS的主要機制及成果，為後續研究提供參考。
關鍵詞: 腸易激綜合徵, 5-羥色胺, 血清素, 中西醫結合, 治療, 綜述
Abstract: Irritable bowel syndrome（IBS） is a gastrointestinal disorder with no structural damage and biochemical abnormality，and its pathogenic mechanism is still unclear. Variety of drugs，psychotherapy，diet regulation and other methods have been used by modern medicine to relieve symptoms，but the effect is not satisfactory. In recent years，TCM treatment of IBS has attracted widespread attention，especially for constipation type and diarrhea type. Among the many experiments，most of the traditional Chinese medicine experiments aimed at the 5-HT signaling pathway have achieved good results. Therefore，this paper summarizes the main mechanisms and results of traditional Chinese medicine based on 5-HT in the treatment of IBS，in order to provide a reference for subsequent research.
Key words: Irritable bowel syndrome, 5-hydroxytryptamine, Serotonin, Integrated traditional Chinese Medicine ＆ western medicine, Therapy, Review
